Middleton is a rural residential locality in the local government areas (LGA) of Kingborough and Huon Valley in the Hobart and South-east LGA regions of Tasmania.

The locality is about 40 kilometres (25 mi) south-east of the town of Huonville.

[1] Permanent European settlement began in Middleton from the 1850s, however, the area had been utilised earlier by the timber and sealing industries and has always been of significance to the Nuenonne band of the South East tribe of Aboriginal people.

[2] The waters of the D'Entrecasteaux Channel form the eastern boundary.

[3] Route B68 (Channel Highway) runs through from north-east to south-east.