Middleton Regional High School is located in Middleton, Annapolis County, Nova Scotia, Canada.

Middleton Regional High School is often abbreviated to MRHS.

The school serves the communities of Middleton, Nictaux, Lawrencetown, Torbrook, Wilmot, Spa Springs, and Margaretsville.

The MRHS Monarchs senior girls' basketball team won four consecutive provincial championships, from 2012 to 2016.

This Nova Scotia school-related article is a stub.