The school opened in 1957 with 30 students in kindergarten and first grade in a building behind the founders' church in downtown Midland.

It moved to three buildings on its current campus in 1963, and after the gradual addition of grades, graduated its first high school class in 1981.

[4] In January 2022, a parent reported an alleged sexual assault in a locker room as part of freshman hazing.

[8] Midland Christian's athletics teams are the Mustangs; it has programs in baseball, basketball, cheerleading, cross country, football, golf, softball, tennis, track and field, and volleyball.

[9] The football team lost to Dallas Parish Episcopal School in the final of the 2021 TAPPS Division 1 Championship.