The original Midland High School was built in 1926 and was moved twenty-three years later to a new building in 1949 where it currently sits today.

In recent years, Midland High School has received major renovations including complete asbestos removal and new West Wing that houses science, math, and social studies classroom.

The practice field of the Midland High football team Memorial Stadium has also received a new turf.

[3] The first building to be officially named Midland High School was built in 1926 on the site of what is now Fasken Center, at 600 Texas Street.

[3] On January 7, 1955, Elvis Presley performed at Midland High along with several other acts from the Louisiana Hayride in what was billed as a "Western Show.

[4] In recent years, Midland High enrollment has grown steadily due to the effects of the oil industry on the Permian Basin region.

To deal with a student population projected to rise by as much as 9,700 students in the next 10 years, the Midland ISD Facility Master Planning Committee presented a plan that calls for $545.8 million bond election in as early May and more than $910 million in total projects over the next decade.

[5] In November 2019, the Midland ISD secondary school bond election resulted in local political drama as the initial vote was close enough to call for a recount.

The boys swimming team, started in 1961, was flourishing by 1968 when MHS alum Doug Russell won two Gold Medals in the 1968 Olympics.