Midnight Resistance (ミッドナイトレジスタンス, Middonaito Rejisutansu) is a side-scrolling run and gun game produced by Data East and released in arcades in 1989.

In the Sega Genesis/Mega Drive version, the main character is Johnny Ford who is a member of an operative group who shuts down drug cartels in South America.

After completing his last mission, Johnny returned home only to find it in shambles, and he sees a note in which King Crimson kidnapped his entire family.

The reason for the abduction is that Johnny's father, Malcolm Ford, was developing a serum which could help people break their addictions to all narcotics.

Although the graphics and stage designs are similar to the arcade version, the controls were changed to accommodate for the lack of a rotatable joystick.

The other configurations are closer to the arcade version's controls, allowing the player to rotate the character's aim clockwise, counter-clockwise, or alternate between the two.

In 1989, Ocean Software published in Europe computer ports for the Commodore 64, ZX Spectrum, Amstrad CPC, Amiga, and the Atari ST, all of which were developed by Special FX.

In Japan, Game Machine listed Midnight Resistance on their December 15, 1989 issue as being the fifth most-successful table arcade unit of the month.

[12] MegaTech magazine praised the weapons and action in the Mega Drive/ Genesis port, but criticized the lack of two-player mode and said that the game was too easy.