The Pappenheimer Mansion, later the Ponce de Leon Infirmary, then Midtown Hospital, was located at 144 Ponce de Leon Avenue NE in Midtown Atlanta, on the north side between Piedmont and Juniper streets.

Furniture magnate Oscar Pappenheimer (1861-1917) built his first house on the site around 1900, which burned down in 1914.

Pappenheimer rebuilt almost immediately, including a famous music room which contained a pipe organ as well as two grand pianos.

[1] By 1941[3] it had become an ear, nose and throat hospital called the Ponce de Leon Infirmary, founded by Dr. Murdock Equen.

[5] The mansion was demolished in 1999 and the Marq on Ponce apartment complex now occupies the site.