Midwest is a town in Natrona County, Wyoming, United States.

It is part of the Casper, Wyoming Metropolitan Statistical Area.

[6] According to the United States Census Bureau, the town has a total area of 0.43 square miles (1.11 km2), all land.

[8] As of the census[2] of 2010, there were 404 people, 148 households, and 104 families living in the town.

20.3% of all households were made up of individuals, and 4.7% had someone living alone who was 65 years of age or older.

26.2% of all households were made up of individuals, and 13.4% had someone living alone who was 65 years of age or older.

Public education in the town of Midwest is provided by Natrona County School District #1.