Powder River is a census-designated place (CDP) in Natrona County, Wyoming, United States.

It is part of the Casper, Wyoming Metropolitan Statistical Area.

A post office called Powder River has been in operation since 1904.

[6] A Chicago and Northwestern Railroad Depot built in 1910 still stands and was listed on the National Register of Historic Places in 1988.

25.0% of all households were made up of individuals, and 12.5% had someone living alone who was 65 years of age or older.