Miguel DePaula Asencio (born September 29, 1980) is a former Major League Baseball pitcher.

Asencio was signed by the Philadelphia Phillies as an amateur free agent on July 2, 1998.

Asencio was named to the Florida State League All-Star Team and was the FSL player of the week from July 16–22.

His Major League debut in relief versus the Chicago White Sox on April 6, 2002, was inauspicious as his first 16 pitches (including a wild pitch to the third batter), were out of the strike zone, forcing in a run before he even threw his first Major League strike.

In January 2008, Asencio signed a minor league contract with the Boston Red Sox and became a free agent after the season.