The Mihai Eminescu High School in Bucharest was established on September 1, 1926, as part of an educational expansion in the early 20th century to meet the growing needs of the city's population.

In 1926, the high school was named after the famous Romanian poet Mihai Eminescu, with approval from the Ministry of Education and a royal decree by King Ferdinand I.

Despite early challenges, including a lack of proper facilities and the need to move locations, the school grew rapidly under subsequent directors.

The founding of the school was driven by local community efforts and aimed to provide accessible education to children from working-class and lower-middle-class families.

Early staff included notable educators and intellectuals, contributing to the high school's reputation for academic excellence and extracurricular achievements.