Until 1990 it was called Mihai Eminescu Natural Science High School (Liceul de Științe ale Naturii).

In 1990, the name was changed to Mihai Eminescu Theoretical High School (Liceul Teoretic) and in 2005 was given the National College (Colegiu Național) title, thus becoming Mihai Eminescu National College (C.N.M.E.

The Mihai Eminescu National College is known today as one of the most prestigious high schools in Constanța.

The school building, built 1906 to 1908, is listed as a historic monument by Romania's Ministry of Culture and Religious Affairs.

[2] Beneath the building's foundation there are under the city's protection several high value historical ruins.