Mesarovic has been a pioneer in the field of systems theory, he was UNESCO Scientific Advisor on Global change and also a member of the Club of Rome.
He has lectured in more than 60 countries, advised government officials on a variety of issues, consulted for international organizations, and published widely.
In that role, Mesarović travelled to UNESCO's headquarters in Paris and advised the director general's office on issues such as climate change, economics, population, technology transfer, and the education of women in developing countries.
[3] In 2005 he was awarded the Hovorka Prize from Case Western Reserve University for exceptional achievements.
In the field of mathematics he is considered to be the founder of: Mesarovic published several books and numerous articles.