It was in Bucharest where he got involved in the Albanian National Awakening where the movement soon collapsed due to financial reasons in the extended family who were dependent on money.

In 1907, he joined the newly formed Çerçiz Topulli's kachak band, an early guerrilla unit fighting against Ottoman troops ( mostly Albanian) and policies of Sultan Abdul Hamid II in Albania.

[4] In 1909 Grameno founded in Korçë the Orthodox League (or Alliance) (Albanian: Lidhja Ortodokse) and served as editor of its periodical with the same name during 1909–1910.

[7] Mihal Grameno was one of the four initial appointed delegates from Korçë to the Albanian National Congress that proclaimed the Independence of Albania on 28 November 1912.

[8] After independence, Grameno served as the editor of the weekly Koha (Time), initially published in Korçë and later in Jamestown, New York, where he lived from 1915 to 1919.