Mikazuki Domain (三日月藩, Mikazuki-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, in Harima Province in what is now the southwestern portion of modern-day Hyōgo Prefecture.
It was controlled by a cadet branch tozama daimyō Mori clan throughout its history.
During the Boshin War, the domain quickly sided with the imperial government.
The clan was ennobled with the kazoku peerage title of shishaku (viscount) in 1884.
As with most domains in the han system, Mikazuki Domain consisted of several discontinuous territories calculated to provide the assigned kokudaka, based on periodic cadastral surveys and projected agricultural yields.