[1][2][3] During the Sengoku period, Takatsuki was ruled by Takayama Ukon, who served Oda Nobunaga and Toyotomi Hideyoshi.

Following Hideyoshi's persecution of the Kirishitan religion, the area was awarded as a 30,000 koku domain to Shinjo Naomori.

In 1615, Naito Nobumasa was transferred to Takatsuki from Nagahama Domain in Ōmi Province and his kokudaka was set at 40,000 koku by the Tokugawa shogunate.

He was replaced by Matsudaira Ienobu from Kasahara in Mikawa Province, but he was transferred to Sakura Domain in Shimōsa in 1635.

The domain then went to Nagai Naokiyo, who transferred his seat from Nagaoka in Yamashiro Province.