In 1608, he appointed Matsudaira Yasushige, who was possibly his illegitimate son, to oversee construction, and as daimyō of the new 50,000 koku Sasayama Domain.
The 4th daimyō, Matsudaira Nobutsuna served as Kyoto Shoshidai and rōjū and invited cultural figures to the domain.
However, his son, Matsudaira Nobumine, was a poor ruler and was injured during peasant uprisings in the Kyōhō famine.
The domain had little economic production other than rice cultivation, and as a result, the clan's finances and territories were often in dire straits.
During the Bakumatsu period, as with almost all domains, the samurai of Sasayama were divided between pro-Tokugawa and pro-sonnō-jōi factions, although the domain itself was regarded as one of the most loyal of the fudai houses the final daimyō, Aoyama Takayuki, served as guard of Nijō Castle in Kyoto and led shogunate forces in the Kinmon Incident.
However, after the start of the Boshin War, when Saionji Kinmochi led an imperial army to Sasayama, the domain surrendered without a fight.