Dr. Victor Frankenstein has completely mastered immortality and has now also created an infinite number of Einstein–Rosen Bridges (wormholes) or "Frankenholes" between Somewhere in Eastern Europe (which is teeming with monsters and supernatural forces) and every time period from the past and the future.

Episodes in the first season were requested to air out of order by the series creator, Dino Stamatopolous, following the show's theme that all time takes place at once and is meaningless.

Lyndon B. Johnson asks Victor Frankenstein to put his brain into the handsome head of the recently deceased John F. Kennedy.

Guest appearance: William Salyers as John Hancock Ron Howard goes back in time in and attempts to kidnap a younger version of himself to transplant his current brain into.

[9] Every episode, with the exception of "Mother To Be-Sa", is available for digital purchase on iTunes,[10] Google Play,[11] Amazon Video[12] and Microsoft.