The anime is directed by Shingo Natsume, with Shinichirō Watanabe serving as general director, and produced by Bones.

The series' opening theme is "Viva Namida" (ビバナミダ, Biba Namida, "Viva Tears") performed by Yasuyuki Okamura and the ending theme is "X-Jigen e Yōkoso" (X次元へようこそ, Ekkusu Jigen e Yōkoso, "Welcome to the Xth Dimension") performed by Etsuko Yakushimaru.

Club gave Space Dandy a B+, stating: "This is a proudly frivolous show, one that delights in its juvenile sense of humor and sneers at the very idea of an ongoing storyline.

The show is a surreal throwback to a bygone era of science fiction, like an old Flash Gordon serial or a wacky Superman comic from the Silver Age – if the heroic protagonist were obsessed with butts and breasts.

"[1] Paul and Caroline Daley of Three If By Space wrote, "Dandy himself both in look and personality, combines Elvis Presley, Zapp Brannigan, and Han Solo.

The bright colors, the music, and especially the main character, the titular Space Dandy, all remind me of a time when adventures didn’t have to make total sense and political correctness wasn’t really a thing yet.

It’s an enjoyable look at Japanese comedic portrayals of different science fiction tropes and styles, but ultimately only good for laughs.

It’s over the top, at times crass, nonsensical, and seeing as it comes from the creative team behind Cowboy Bebop, not without its fair share of great music."

and "There’s not much over-arching narrative for the season, and episodes are their own self-contained storylets, but the formula works perfectly, letting Space Dandy mess around with a bunch of different ideas while never straying too far from its strong comedy backbone.