Mishustin confirmed his test results in a video conference with President Vladimir Putin, and nominated his deputy to take over for him as acting Prime Minister.

Putin signed a decree appointing Andrey Belousov to the role on an acting basis, following Mishustin's recommendation.

[3] Medvedev resigned after President Vladimir Putin, during his Address to the Federal Assembly, proposed amendments to the Constitution that would change the balance of power.

Since United Russia has more than half of the seats in the State Duma, this means that Mishustin would become Prime Minister, even if all other parties voted against it.

[11] During a meeting with the Communist Party, Mishustin announced drastic changes in the structure and personal composition of the government.

According to State Duma Speaker Vyacheslav Volodin, from members of the previous cabinet, all factions expressed support for the power and international blocs, three Deputy Prime Ministers: Tatyana Golikova, Dmitry Kozak and Alexey Gordeyev, as well as Agriculture Minister Dmitry Patrushev.

[14][15] The Liberal Democratic Party also criticized Yury Trutnev, the Deputy Prime Minister and Presidential Envoy to the Far Eastern Federal District.

[20] On 26 March 2020, Mishustin proposed to restore the Government's Presidium, a body in the structure of the Cabinet formed to solve operational issues.

Since the reshuffle took place after the adoption of amendments to the Constitution and the new law on government, all appointments must be approved by the State Duma.

[31] On 25 May 2022, the Federation Council approved Kurenkov's candidacy with 159 votes in favor, and on the same day he was appointed minister by presidential decree.