Youzhny was a member of the winning Russian national team at the Davis Cup in both 2002 and 2006, playing a crucial role in 2002 when he won the deciding rubber after coming back from two-sets-to-love down.

[7] His good form continued and he won his first ATP tour-level match at the 2000 edition of the Rosmalen Grass Court Championships by defeating 154-ranked Canadian Daniel Nestor.

[7] At the Kremlin Cup tournament in Moscow, Youzhny reached his first ATP tour-level quarterfinals, beating 36-ranked Frenchman Fabrice Santoro and 60-ranked Swede Thomas Johansson, but lost to Marc Rosset, 35th in the world.

[8] He continued his good form into February, reaching his first ATP tour-level semifinals at the 2000 Copenhagen Open, but lost to eventual runner-up Andreas Vinciguerra from Sweden.

[13] At the Grand Prix Hassan II tournament in Casablanca, Youzhny reached his first ATP tour-level semifinal, but lost to Younes El Aynaoui in straight sets.

[12] In the next tournament, Youzhny reached the quarterfinals of the Gerry Weber Open in Halle, Germany, losing to world number ten Roger Federer in straight sets.

[14] At the Mercedes Cup in Stuttgart, Youzhny won his first ATP-tour level title in a five-set victory over Argentinian world number nineteen Guillermo Cañas.

[16] Youzhny, who was seeded for the first time at a grand slam event, reached the fourth round of the Australian Open losing to world number nine Andy Roddick in five sets after failing to close out the match with a two-set lead.

[18] His good form continued into the French Open, where he had wins over Dennis van Scheppingen and Andrei Pavel, but was eliminated in the third round by Nicolas Escudé in four sets.

[23] After a third round loss to Guillermo Coria at the China Open, Youzhny reached the quarterfinals of the Kremlin Cup where he was upset by wild card entry Dmitry Tursunov.

[25] However, Youzhny steadily improved by reaching the quarterfinals of the PBS Zabreb Indoors and then the semifinals of the Dubai Tennis Championships, defeating players such as Dominik Hrbatý and Igor Andreev on the way.

[35] He reached the quarterfinals of the Paris Masters with wins over Arnaud Clément, Fernando González and Tommy Haas, but lost in straight sets to Rafael Nadal.

[36] His poor form continued into the clay season, but Youzhny, as the 15th-seed, managed to reach the third round of the French Open, losing to world number twenty-three Fernando Verdasco from Spain in four sets.

[36] At his next tournament, the Allianz Suisse Open Gstaad in Switzerland, Youzhny reached his last quarterfinals of the season and lost to Spain's Guillermo García López.

[40] He reached back-to-back quarterfinals at ABN AMRO World Tennis Tournament in Rotterdam and the Open 13 in Marseille, defeating David Ferrer and Tomáš Berdych on his way.

[41] Youzhny continued his good form by reaching the semifinals of the Interwetten Austrian Open Kitzbühel in Austria, and lost to world number seventy-four and eventual champion Guillermo García López in three sets.

[40] At Wimbledon Youzhny failed to defend his ranking points earned the previous year, and lost in the first round to Spain Juan Carlos Ferrero.

[40] However, Youzhny immediately bounced back by reaching the quarterfinals of the Proton Malaysian Open in Kuala Lumpur, where he lost to world number twelve Fernando González.

[54] Youzhny's season ended when he was forced to retire with a back injury against world number twenty-six Ernests Gulbis at the BNP Paribas Masters in Paris.

[56] Youzhny was seeded 12th at the French Open, and lost in the third round to world number thirty-eight Albert Montañés, a Spanish clay-court specialist, in straight sets.

Youzhny also participated in the mixed doubles event, partnering Elena Vesnina, and lost in the first round against Gisela Dulko and Juan Martín del Potro from Argentina.

[65] In his first post Australian Open tournament, Youzhny failed in his bid to defend his title at the PBZ Zagreb Indoors, losing to world number twelve Marin Čilić at semifinal.

On 8 November, he won his first ATP challenger event champion since 2000, Bauer Watertechnology Cup at Eckental, Germany, defeating 4th seed Benjamin Becker straight sets in the final.

Youzhny finished his 2016 season with a five-match losing streak, with four more matches lost at Antwerp, Basel, Paris Masters Qualifying and the Challenger event at Mouilleron-le-Captif.

Youzhny started his 2017 season at the 2017 Aircel Chennai Open, where he reached the quarterfinals by beating Indian Saketh Myneni and Argentine Renzo Olivo without losing a set.

[citation needed] The matches were hosted by Israel in the World Group quarterfinal tie in July 2009, on indoor hard courts at the Nokia Arena in Tel Aviv.

[83] Youzhny resigned from the Russian Davis Cup team in February 2011, stating, "I think the time has come for me step aside and give younger players a chance".

[86] In his last Davis Cup match so far, in 2012, Youzhny partnered with Nikolay Davydenko to beat Austria doubles team Oliver Marach and Alexander Peya.

[60] In the mixed doubles, however, he and teammate Elena Vesnina lost in the first round in straight sets to the Argentine team of Gisela Dulko and Juan Martín del Potro.

[98] The Russian government awarded Youzhny the title Honoured Master of Sports in 2003 for his participation in Russia's Davis Cup victory the previous year.