It spreads by means of an insect vector, the identity of which is unknown.

In general, phytoplasmas spread via leafhoppers and other sap-sucking insects that transmit the pathogen from one host plant to another.

As of November 2021[update], milkweed yellows phytoplasma has not been formally described.

Other diseases caused by pathogens in subgroup 16SrIII-F include Vaccinium witches' broom, potato purple top, and a greening disorder of Trillium grandiflorum and other Trillium species.

[citation needed] This plant disease article is a stub.