Mill Creek is a borough in Huntingdon County, Pennsylvania, United States.

The creek was the main source of power for many of the mills in the settlement years of the 1700s, as well as during much of the nineteenth century.

U.S. Route 22 passes through the borough, leading northwestward 5 miles (8 km) to Huntingdon, the county seat, and southeastward 6 miles (10 km) to Mount Union.

The racial makeup of the borough was 99.15% White, 0.28% African American, and 0.57% from two or more races.

17.5% of all households were made up of individuals, and 11.9% had someone living alone who was 65 years of age or older.