It flows 28.4 miles (45.7 km)[1] southwest and south from its headwaters in Liberty Township of Butler County through central Hamilton County and the heart of Cincinnati into the Ohio River just west of downtown.
The Mill Creek Valley is a remnant of the Deep Stage Ohio River from the days of the Last Glacial Maximum.
Finally, inclined planes solved the problem, before highways and automobiles eliminated it.
Throughout Cincinnati's history, Mill Creek has been the scene of heavy industry.
"[3] A USGS stream gauge on the creek at Mitchell Avenue in Cincinnati recorded a mean annual discharge of 115.9 cubic feet per second (3.28 m3/s) during the four combined water years 1942-1943 and 1946–1947.