It runs between St Georges Terrace and Mounts Bay Road.

The street was named after a mill built in 1833 by Samuel Kingsford.

[3] Prior to extensive landfill since the 1950s, the street ended close to the Swan River.

[7][8] Mill Street is the main connection for buses leaving the Elizabeth Quay Bus Station, and moving along St Georges Terrace before leaving the CBD.

[9] It is the location of the Parmelia Hilton hotel, where a significant number of conferences and events have been reported and published as being conducted in Mill Street.