Millbury High was originally located on 130 Elm Street, which is now occupied by the Mary Elizabeth McGrath Educational Center.

[2] The school was then also dedicated as a memorial to local World War II veterans.

Home of the Woolies, Millbury athletic teams primarily sport the colors of maroon, gold, and white.

Current sport offerings at the school include: basketball, cheerleading, cross country, football, golf, soccer, baseball, softball, track and field, and volleyball.

Michael Favulli is known to have coached sports at Millbury High.