It drains parts of the Semien (North) Wollo and Debub (South) Wollo Zones of the Amhara Region, as well as Administrative Zone 4 of the Afar Region.

Nesbitt, who travelled through the area in 1928, was impressed by its size, and described the Mille as "probably the only real river which joins the Awash".

[4] The Mille River rises in the Ethiopian Highlands west of Sulula in Tehuledere woreda in Amhara Region.

It flows first to the north, then curves to run east to its confluence with the Awash at 11°25′N 40°58′E / 11.417°N 40.967°E / 11.417; 40.967.

This article related to a river in Ethiopia is a stub.