Millis-Clicquot is a census-designated place (CDP) in the town of Millis in Norfolk County, Massachusetts, United States.

[3] According to the United States Census Bureau, the CDP has a total area of 8.1 km2 (3.1 mi2), of which 3.1 mi2 (8.0 km2) is land and 0.04 mi2 (0.1 km2) (0.64%) is water.

As of the census[5] of 2000, there were 4,607 people, 1,860 households, and 1,231 families residing in the CDP.

The racial makeup of the CDP was 96.83% White, 1.02% Black or African American, 0.09% Native American, 1.17% Asian, 0.13% from other races, and 0.76% from two or more races.

28.5% of all households were made up of individuals, and 9.2% had someone living alone who was 65 years of age or older.