[1][2] In early 1828, the Millsburg settlement was established in an agreement between Colonial Agent Jehudi Ashmun and Dei chiefs.

[5] Millsburg is named for Samuel John Mills and Ebenezer Burgess, two agents of the American Colonization Society (ACS) who in 1818 made a reported on the British colony of Sierra Leone and its viability as a colony for African-American emigrants.

[4] In 1835, Mississippi Colonization Society sponsored its first group of African-American emigrants to Liberia, with most of the 71 people settling in Millsburg.

[9] In a book published in 1850, James W. Lugenbeel described Millsburg as the Liberian settlement furthest from the sea coast.

Under the 2023 to 2028 electoral map, Millsburg is a part of Montserrado County's 17th House of Representatives district.