Millstone Creek is a 7.08 mi (11.39 km) long 3rd order tributary to the Deep River in Randolph, North Carolina.

Millstone Creek rises on the Brush Creek divide about 0.1 miles south of Browns Crossroads in Randolph County, North Carolina and then flows southwesterly to join the Deep River about 2 miles southwest of Parks Crossroads, North Carolina.

[2] Millstone Creek drains 10.02 square miles (26.0 km2) of area, receives about 47.3 in/year of precipitation, and has a wetness index of 389.06 and is about 37% forested.

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