The school met all twelve indicators on the 2009-2010 Ohio Department of Education report card, earning an "Excellent" rating.

Municipalities covered by the district include Laura, Ludlow Falls, Potsdam, and West Union.

Milton-Union competes in the newly formed (as of 2021) Three Rivers Conference (TRC).

Milton-Union rejoined the Southwestern Buckeye League in 2001 until 2021 and then the newly formed Three Rivers Conference in 2021.

West Milton High School (the predecessor of Milton-Union) never competed in a league.