Minami-Matsumoto Station (南松本駅, Minami-Matsumoto-eki) is a train station in the city of Matsumoto, Nagano Prefecture, Japan, operated by East Japan Railway Company (JR East)., with a freight terminal operated by the Japan Freight Railway Company.

Minami-Matsumoto Station is served by the Shinonoi Line and is 10.9 kilometers from the terminus of the line at Shiojiri Station.Many trains of the Chūō Main Line continue past the nominal intermediate terminus of the line at Shiojiri and continue on to Matsumoto via this station.

The station has a Midori no Madoguchi staffed ticket office.

[1] Minami-Matumoto Station opened on 1 September 1944.

With the privatization of Japanese National Railways (JNR) on 1 April 1987, the station came under the control of JR East.