The Ministry of Defence (MINDEF; Malay: Kementerian Pertahanan; Chinese: 新加坡國防部; Tamil: தற்காப்பு அமைச்சு) is a ministry under the Government of Singapore responsible for overseeing the national defence of Singapore.

MINDEF's mission is to "enhance Singapore's peace and security through deterrence and diplomacy, and should these fail, to secure a swift and decisive victory over the aggressor.

MINDEF has one statutory board, the Defence Science and Technology Agency (DSTA).

The Ministry is headed by the Minister for Defence, who is appointed as part of the Cabinet of Singapore.

The incumbent minister is Bishan-Toa Payoh GRC MP Ng Eng Hen from the People's Action Party.