[4] Cohn was discovered by actress Charlotte Rae when Rae and the producers of The Facts of Life visited Westlake School in Holmby Hills, California, while doing research for the show;[5] she had been asked by the principal to be a student tour guide for the group, who found themselves enchanted by her natural comic instincts as she led them around the campus.

It seemed that Charlotte Rae had fallen madly in love with me, in part because I reminded her of her best childhood friend Natalie—and I was irrepressible, charming, and hilarious.

She appeared in an episode of Hot in Cleveland on July 13, 2011, on The Secret Life of the American Teenager on March 26, 2012, in Judson Theatre Company's Bell, Book and Candle in 2013,[11] and in The Middle on May 21, 2014.

[14][15] She has a degree in cultural anthropology from Loyola Marymount University[16] and is a founding member of the weSpark cancer support center.

[17] In 2003 Cohn was nominated for a Daytime Emmy Award for her work on the TV show What's New, Scooby-Doo?, for which she provided the voice of Velma Dinkley.

Cohn received a positive notice from Variety for her role in the 2007 Daniel Waters comedy film Sex and Death 101.