Proposals in 1716 for a hospital to receive them were supported by Lady Elizabeth Hastings, Henry Hoare, Joseph Jekyll, William Oliver, Beau Nash and others.

The original building, designed by John Wood the Elder, was built with Bath stone donated by Ralph Allen and completed in 1742.

[9] Construction started on a building at the RUH's Combe Park site in November 2017, to house the Royal National Hospital and the Brownsword Therapies centre.

[12] Five 18th-century oil paintings from the Mineral Water Hospital were re-hung at the RUH,[13] notably a work of William Hoare titled Dr Oliver and Mr Pierce examining patients with Paralysis, Rheumatism and Leprosy.

[15] Nationally commissioned specialist services include: The historic city centre site at Upper Borough Walls was offered for sale by the RUH Trust in 2017.

[21][22][23] The planning committee of Bath and North East Somerset Council had rejected a 2020 application by Fragrance Group, after the proposed extension was criticised for its size and height.