The ministry is responsible for coordinating all government programs in the five districts of the Karamoja sub-region.

[1] John Byabagambi currently serves as the Minister for Karamoja Affairs.

[2][3][4] The headquarters of the ministry are located in the Twin Towers on Sir Apollo Kaggwa Road, in the Central Division of Kampala, Uganda's capital and largest city.

[5] The ministry is part of the Office of the Prime Minister of Uganda.

[2][3] Christine Guwatudde Kintu serves as the ministry's chief accounting officer.