The Ministry of Cultures, Decolonization, and Depatriarchalization (Spanish: Ministerio de Culturas, Descolonización, y Despatriarcalización) is the ministry of the government of Bolivia that provides for the preservation and protection of the cultures and artistic expressions of the indigenous peoples of Bolivia as well as promotes the country's tourism sector and process of decolonization and depatriarchalization.

[1] In 2006, during the early government of President Evo Morales —Bolivia's first indigenous president— the office was expanded as the Vice Ministry of Cultural Development.

On 7 February 2009, through Chapter XX of Supreme Decree N° 29894 on the Organizational Structure of the Executive Body of the Plurinational State, Morales formed the Ministry of Cultures.

[4] The transitional government of Jeanine Áñez eliminated the portfolio on 4 June 2020 to preserve funds to combat the COVID-19 pandemic, a decision criticized by both the opposition and members of Morales' Movement for Socialism (MAS-IPSP).

[5][6] After the return to power of the MAS in that year's general elections, President Luis Arce restored the office as the Ministry of Cultures, Decolonization, and Depatriarchalization on 13 November 2020.