The Ministry of Higher Education, Science and Culture (MESCC; Portuguese: Ministério do Ensino Superior, Ciência e Cultura, Tetum: Ministériu Ensinu Superiór, Siénsia no Kultura) is the government department of East Timor accountable for higher education and related matters.

The Ministry is responsible for the design, implementation, coordination and evaluation of policy for the following areas:[1] The ministry oversees the National Agency for Academic Assessment and Accreditation (ANAAA; Tetum: Ajénsia Nasional ba Avaliasaun no Akreditasaun Akadémika), East Timor's national accreditation agency for higher education institutions, established in 2010.

[2] The incumbent Minister of Higher Education, Science and Culture is José Honório da Costa Pereira Jerónimo.

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