The Ministry of Industry, Trade and MSMEs (Spanish: Ministerio de Industria, Comercio y Mipymes) of the Dominican Republic is a government institution in charge of formulating, evaluating and supervising the country's policies, plans and projects related to industries, exporting, internal trade, external trade, industrial zones and micro, small and medium-sized enterprises (MSMEs).

This document specified that:There will be four Ministers-Secretaries of State and of the following Departments: first, of Justice and Public Instruction; second, of the Interior and Police; third, of Finance and Trade; fourth of War and Navy.A few days later, on November 14, 1844, the office was officially created as the Secretary of State of Finance and Trade (Secretaría de Estado de Hacienda y Comercio), being its first ministre-secretary Ricardo Miura.

[5] It wouldn't be until 1934 that an office specifically dedicated to industry and trade was created by Law no.

It adopted the name Ministry of Industry and Trade (Ministerio de Industria y Comercio), after the 2010 Constitutional reform and the subsequent Decree no.

[9] This gave more weight to micro, small and medium-sized enterprises (MSMEs or Mipymes in Spanish).