The highway travels from the southern region of Anchorage northward to North Star neighborhood area, and bisects the community of Spenard.

The entire length of the expressway is listed on the National Highway System,[3] a network of roads important to the country's economy, defense, and mobility.

[2] The highway passes over C Street and continues past a few small properties before curling north and becoming renamed Minnesota Drive.

[7] The expressway passes two small lakes, with a southbound exit for Hillcrest Drive, which provides access to West Anchorage High School.

[8] The highway continues northward, merging with Spenard Road and passing a small neighborhood, before intersecting 15th Avenue, where the expressway terminates.

[5] The Minnesota Drive Expressway was first created circa 1950, when the Spenard Road was built in the location of the current highway.