Minnesota State Highway 110 (MN 110) was a short 5+1⁄4-mile-long (8.4 km) connector state highway in Minnesota, which ran from an interchange with MN 55 in Mendota Heights to an interchange with Interstate 494 (I-494) in Inver Grove Heights, south of downtown Saint Paul.

The highway also had an interchange with Robert Street/Robert Trail (MN 3) in Inver Grove Heights.

The western terminus of MN 110 was located near the confluence of the Minnesota and Mississippi rivers at the Mendota Bridge.

[citation needed] This route was originally part of the MN 100 Beltway circling the entire Twin Cities during the 1940s and 1950s.

[citation needed] Before completion of the I-494 freeway in 1985, I-494 had a missing link for 20 years.