Minnesota State Highway 22 (MN 22) is a 166.325-mile-long (267.674 km) highway in south-central and central Minnesota, which runs from Winnebago County Road R50 at the Iowa state line near Kiester and continues north to its northern terminus at its intersection with State Highway 23 in Richmond, west of St.

State Highway 22 serves as a north–south route between Wells, Mankato, St. Peter, Gaylord, Glencoe, Hutchinson, Litchfield, and Richmond.

The southern terminus for Highway 22 is at the Iowa state line, near Kiester, where Highway 22 becomes Winnebago County Road R50 (140th Avenue) upon crossing the state line.

When the parallel route west of the Minnesota River was first completed in the late 1950s, it originally carried the Highway 22 designation for a few years until it was redesignated U.S. 169 and Highway 22 reverted to its original alignment.

[1] Highway 22 will be redone from Mapleton to CO RD 90 just south of Mankato starting March 27, 2017, with the project finalizing in 2019.