State Highway 6 serves as a north–south route between Bay Lake Township, Deerwood, Crosby, Remer, Deer River, and Big Falls in east-central and north-central Minnesota.

The route passes through the Chippewa National Forest in Cass and Itasca counties.

Highway 6 passes through the following state forests: Schoolcraft State Park is located on Highway 6 in Cass County on the banks of the Mississippi River.

The park is located south of Deer River and west of Grand Rapids.

State Highway 6 was authorized in 1920 between Remer and Big Falls.