State Highway 80 serves as an east–west route in southeast Minnesota between Wykoff and Fountain.

The route is located near the cities of Spring Valley and Preston.

The roadway passes through the Richard J. Dorer State Forest.

Legally, it is part of Constitutional Route 9 as defined in the Minnesota Statutes.

[1] The route was previously U.S. 16 until that designation was moved to a bypass of Wykoff and Fountain.