Mino-Sakamoto Station (美乃坂本駅, Mino-Sakamoto-eki) is a railway station on the Chūō Main Line in the city of Nakatsugawa, Gifu Prefecture, Japan, operated by Central Japan Railway Company (JR Central).

Mino-Sakamoto Station is served by the Chūō Main Line, and is located 323.4 kilometers from the official starting point of the line at Tokyo and 73.5 kilometers from Nagoya.

The station has one ground-level island platform connected by a footbridge.

The station has a Midori no Madoguchi staffed ticket office.

On 1 April 1987, it became part of JR Central.