They play a surprising role in heritability since MAF variants which occur only once, known as "singletons", drive an enormous amount of selection.
[1] Single nucleotide polymorphisms (SNPs) with a minor allele frequency of 0.05 (5%) or greater were targeted by the HapMap project.
The authors classified the variants found in the study in three classes according to their MAF.
It was observed that rare variants (MAF < 0.05) appeared more frequently in coding regions than common variants (MAF > 0.05) in this population.
Introduce the reference of a SNP of interest, as an example: rs429358, in a database (dbSNP or other).