Minsleben is on the northern edge of the Harz mountains in the plain open to the north.

Connecting roads lead from Minsleben to Wernigerode, Reddeber, Heudeber and Silstedt.

In the village was a noble court, which had been in the possession of the Reiffenstein family for a long time.

The manor house is now partially used as a residential building, the associated park is open to the public.

At the beginning of the 20th century, a Minsleben train worker cut 89 shrubs and trees along the railway line into human and animal shapes.