The manga is about two twins with opposite interests and talents, but combined ESP abilities (telepathy and teleportation) when they linked their pinkies together.

It was adapted into an anime series by Japan Taps in 1993, starting in January and finishing in December of that year.

However, the science teacher, Shinichiro Kageura, finds out about their psychic powers, and begins to stalk Tomomi.

Anime Episode 1: Tomomi and Mikage are twin high school girls with powers hidden to everyone but themselves and their boyfriends: They can communicate with each other telepathically, and if they hold hands, they can teleport.

One day, they receive big news: Mikage's boyfriend, Kurashige, is transferring to England to further his education; in addition, the ESP fanatic Kageura, the chemistry teacher, is getting married.

Meanwhile, four flowers, two in England outside of a castle and two in Japan outside of the twins' house, suddenly begin to shine and bloom.

Dio performs the ending theme for all 51 episodes, "Futari ja Nakya Dame na no".

The Italian dub used its own opening theme ("È un po' magia per Terry e Maggie" by Cristina D'Avena).

A video game adaptation of Miracle Girls was developed by Now Production and released for the Super Famicom by Takara on October 22, 1993.

Some characters also appeared in the crossover Nakayoshi All-Stars: Mezase Gakuen Idol for the Nintendo DS.

Adam Arnold of Animefringe praised the manga series, particularly for the detailed an expressive eyes, and the story "light-hearted and fun to read".