The win allowed the Eagles to progress to the 2010 NFL playoffs by head-to-head tiebreaker over the Giants, where they lost to the eventual Super Bowl champion Green Bay Packers.
The Giants were unable to capitalize on the turnover, as linebacker Moise Fokou sacked quarterback Eli Manning putting them out of field goal range and forcing them to punt.
Near the end of the quarter, safety Quintin Mikell picked off Manning's pass to wide receiver Derek Hagan and ran it back to the Giants 45-yard line.
The final play of the first quarter resulted in a run by Vick for 11 yards and a personal foul called on tackle Jonathan Goff which moved the ball to the Giants 19-yard line.
But on third down, Vick was sacked for a 4-yard loss by defensive tackle Rocky Bernard, forcing the Eagles to settle for a 34-yard field goal from kicker David Akers.
The Eagles tried to get something going on the next drive and it appeared they did when Vick found wide receiver Jeremy Maclin, but the ball came loose before he hit the ground.
On the next drive, Manning found Manningham but the ball came loose and defensive tackle Mike Patterson recovered it for the Eagles on the Giants 25-yard line.
Replays showed that linebacker Jonathan Goff touched Jackson's jersey as he was falling, meaning that the call on the field of a fumble was incorrect.
On third down and 4 from the Eagles' 8-yard line, Manning hit Boss in the back of the end zone to give the Giants a 31–10 lead with 8:17 remaining in the game.
It was unclear whether the Eagles intentionally had only 10 men on the field, as Giants special teams captain Chase Blackburn stated after the game that he believed it was on purpose.
On the second play of the ensuing drive, Vick escaped a New York blitz and rushed all the way down to the Giants' six-yard line.
After two incomplete passes, with an offsides on Tuck in between, Vick ran the ball into the end zone on third and goal from the four-yard line, making the score 31–24 with 5:28 left in the game.
After two incomplete passes to begin the drive, Vick escaped a blitz by scrambling to his left for 33 yards before stepping out of bounds at the Eagles' 45-yard line.
Jackson ran through a group of Giants and made it to midfield before receiving a huge block by wide receiver Jason Avant on DeOssie, leaving no one in front of Jackson on the way to the end zone (Avant actually gave himself a concussion on the block, and both players were left lying on the field for the rest of the play).
Giants head coach Tom Coughlin was so livid he threw his play sheet and notes onto the ground and ran onto the field before Jackson even reached the end zone, yelling at Dodge for not punting the ball out of bounds.
DeSean Jackson!Quick: OH!Reese: I don't care if he jumps, dives, he's running around and he's in the end zone, and there's no time, and the Eagles win!
*Completions/Attempts aCarries bLong play cReceptions tTackles gForced Fumble The win allowed the Atlanta Falcons, who would beat the Seattle Seahawks 34–18 later that day, to clinch a playoff spot.
In the following week, the Green Bay Packers defeated the Giants, 45–17, enabling Philadelphia to clinch the NFC East division title.