[1] Miria Kalule was born in Kawempe, to Bulasio Kalule, a civil servant who worked with the Department of Road Maintenance in the Ministry of Works[2] and his wife Malita.

[4][5] Miria Obote returned to Uganda from Zambia in October 2005,[6] after 20 years in exile, to bury her husband.

She garnered 0.6% of the vote in the February 23, 2006 presidential election, which was won by the sitting president, Yoweri Museveni.

Miria married Milton Obote in November 1963[9][10] and they had 4 children, including Jimmy Akena, a Member of Parliament representing Lira Municipality.

[11] Milton Obote died on 10 October 2005 in Johannesburg, South Africa, at the age of 79; and received a state funeral in Kampala, Uganda, attended by President Yoweri Museveni.