[2] She began writing in 1906, publishing her first piece that year in the Yiddish newspaper Di idishe fon.
[4] Karpilove would later draw on this experience in her 1926 novel A Provints-Tsaytung, whose protagonist is an undervalued journalist at a small newspaper.
Karpilove was known for her serialized novels focusing on the lives of Jewish immigrant women in New York.
[5] In her works, Karpilove used the form of letters and diary entries to express her characters' feelings and thoughts.
[6] She served on the executive board of the Women's Jewish Congress Organization, a group working to ensure full political rights for Jews in foreign countries.